ITGA4

  • Official Full Name

    integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

  • Overview

    The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.

  • Synonyms

    ITGA4;integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor);IA4;CD49D

Recombinant Proteins

  • Mouse
  • Human
  • CHO
  • E.coli
  • Human Cells
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • His
  • Non
  • Avi
  • Fc
  • GST
  • DDK
  • Myc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
Itga4-5665M Active Recombinant Mouse Integrin Alpha 4, His-tagged CHO Mouse His 34-970;21-728 a.a.
ITGA4-1541H Recombinant Human ITGA4 protein, His-tagged E.coli Human His 131-275 a.a.
ITGA4-161H Recombinant Human ITGA4 & ITGB1, Flag & His tagged Human Cells Human His 1-970;1-728 a.a.
ITGA4-8350M Recombinant Mouse ITGA4 Protein Mammalian Cells Mouse His
ITGA4-5133HCL Recombinant Human ITGA4 293 Cell Lysate HEK293 Human Non
ITGA4-1210H Recombinant Human ITGA4 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
ITGA4-1210H-B Recombinant Human ITGA4 Protein Pre-coupled Magnetic Beads HEK293 Human
Itga4-1696M Recombinant Mouse Itga4 Protein, His-tagged E.coli Mouse His Ala41-Phe226
ITGA4-2321H Recombinant Human ITGA4 protein(376-558aa), His-GST-tagged E.coli Human GST&His 376-558aa
ITGA4-2340H Recombinant Human ITGA4 Protein, His-tagged E.coli Human His Asn35-Leu315
ITGA4-3169H Recombinant Human ITGA4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
Itga4-3595M Recombinant Mouse Itga4 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
ITGA4-4319H Recombinant Human ITGA4 Protein (Met1-Thr977), C-His tagged Mammalian Cells Human His Met1-Thr977
ITGA4-4637M Recombinant Mouse ITGA4 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
ITGA4-4637M-B Recombinant Mouse ITGA4 Protein Pre-coupled Magnetic Beads HEK293 Mouse
ITGA4-4997H Recombinant Human ITGA4 Protein, GST-tagged Wheat Germ Human GST
ITGA4-4998H Recombinant Human ITGA4 Protein Wheat Germ Human Non
ITGA4-5707HF Recombinant Full Length Human ITGA4 Protein In Vitro Cell Free System Human Full L. 755 amino acids
ITGA4-664HFL Recombinant Full Length Human ITGA4 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.

    Involved Pathway

    ITGA4 involved in several pathways and played different roles in them. We selected most pathways ITGA4 participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Dilated cardiomyopathy MYL2,ITGB6,TGFB3,Adcy4,TGFB1,TNNC1,ITGB8,TPM4,PRKACB,CACNA2D4
    Leukocyte transendothelial migration CLDN18,PIK3CB,CLDN2,PIK3R5,ITGB1,VAV2,ICAM1,JAM2,AASS,ARHGAP5
    ne network for IgA production LTBR,CXCL12B,CXCR4A,Il2,CD28,CCL25B,ITGB7,HLA-DRB4,BLB1,BMA2
    Hypertrophic cardiomyopathy (HCM) ACTB,CACNG1,ITGA9,ACTC1,CACNG7,PRKAA2,ITGB6,ACTG1,ITGA2B,SGCB
    Regulation of Actin Cytoskeleton RAC1A,NRAS,HRASB,PIP5K1AA,MAP2K2B,LIMK2,FGF8,FGFR1,CFL2L,GNA12
    Cell adhesion molecules (CAMs) VCAN,PVRL2,CLDNF,CLDND,LRRC4B,CLDN3,F11R.1,H2-Q10,NCAM1,NEO1A
    PIK-Akt signaling pathway TNXB,MAPK3,TSC2,IKBKB,ITGA10,DDIT4,PIK3R3,LPAR3,IL7R,FGF10
    ECM-receptor interaction VTNB,COL6A2,ITGB7,SDC4,LAMA1,ITGA8,LAMA2,COL1A2,ITGB1,ITGA5
    Leishmaniasis H2-AB1,TNF,TGFB1,HLA-DOA,MAP3K7,CYBA,IL4,IRAK1,IRAK4,CR1

    Protein Function

    ITGA4 has several biochemical functions, for example, cell adhesion molecule binding,fibronectin binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA4 itself. We selected most functions ITGA4 had, and list some proteins which have the same functions with ITGA4. You can find most of the proteins on our site.

    Function Related Protein
    protein binding WBP2NL,NIPA2,DPM3,PPP6R3,ALOX5AP,KBTBD7,CD164,CCDC9,ARID3A,PLEKHG6
    protein antigen binding EP300,H2-AB1,KLRC2,KLRD1
    metal ion binding GMIP,NUDT17,NKD2B,ZYMND12,ICN,ATP8A1,ZNF398,RBAK,ZFP593,PRKCBB
    fibronectin binding CTGF,FSTL3,PLEKHA2,IGFBP5A,CTSK,FBLN1,HSD17B12,IGFBP5,LPA,CTSS
    cell adhesion molecule binding NLGN3,AMICA1,CADM2A,TIGIT,CADM1,CADM1B,PVRL2,FGG,LILRB2,NLGN2

    Interacting Protein

    ITGA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA4.

    PXN;ITGB1;VCAM1;LYN;TGFB1I1;LPXN;ITGB1;FLNA

    Resources

    Research Area

    References

    • Ullah, M; Sittinger, M; et al. Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units. MATRIX BIOLOGY 32:452-465(2013).
    • Reindel, R; Baker, SC; et al. Integrins alpha 4 and alpha M, collagen1A1, and matrix metalloproteinase 7 are upregulated in acute Kawasaki disease vasculopathy. PEDIATRIC RESEARCH 73:332-336(2013).

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